Superoxide, nitric oxide and peroxynitrite.
نویسندگان
چکیده
منابع مشابه
Nitric Oxide, Superoxide, Hydrogen Peroxide, and Peroxynitrite
The evanescent nature of reactive oxygen and nitrogen species, the multiple cellular mechanisms evolved to maintain these substances at low (submicromolar) concentrations within the vascular system, and the often multifaceted nature of their reactivities have made measurement of these compounds within the vasculature problematic. This review attempts to provide a critical description of some of...
متن کاملSuperoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.
The Escherichia coli and recombinant human cytosolic aconitases are inactivated by O2-., with a rate constant of approximately 3 x 10(7) M-1 s-1; the corresponding value for the porcine mitochondrial aconitase is approximately 0.8 x 10(7) M-1 s-1. Nitric oxide, which is reported to inactivate aconitase, did not do so at a perceptible rate, while incubation with peroxynitrite led to a rapid loss...
متن کاملPathological implications of nitric oxide, superoxide and peroxynitrite formation.
Introduction Approximately 6 years ago, nitric oxide was identified as the endothelium-derived relaxing factor (EDRF), the endogenous vasodilator mimicked by nitroglycerin and nitroprusside [ 1-41. An astonishing variety of tissues synthesize nitric oxide, which has important roles in the control of systemic blood pressure, respiration, digestion, penile erection, platelet aggregation, cerebral...
متن کاملReaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
Peroxynitrite (ONOO(-)/ONOOH), the product of the diffusion-limited reaction of nitric oxide (*NO) with superoxide (O(-*)(2)), has been implicated as an important mediator of tissue injury during conditions associated with enhanced *NO and O(-*)(2) production. Although several groups of investigators have demonstrated substantial oxidizing and cytotoxic activities of chemically synthesized pero...
متن کاملNitric Oxide / Peroxynitrite :
A large number of research groups have proposed that chronic fatigue syndrome (CFS), fibromyalgia (FM), multiple chemical sensitivity (MCS) and, in some cases, posttraumatic stress disorder (PTSD) have multiple overlaps and may share a common etiology (cause). They have: • overlapping symptoms • many people are diagnosed as having more than one • cases of each are commonly initiated by a short ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1998
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.112.169